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Do osteocytes convert to osteoblast?
OSTEOCYTES are cells inside the bone. They also come from osteoblasts. Some of the osteoblasts turn into osteocytes while the new bone is being formed, and the osteocytes then get surrounded by new bone. They are not isolated, however, because they send out long branches that connect to the other osteocytes.
Are osteoblasts surrounded by bone matrix?
osteoblast, large cell responsible for the synthesis and mineralization of bone during both initial bone formation and later bone remodeling. Eventually the osteoblast is surrounded by the growing bone matrix, and, as the material calcifies, the cell is trapped in a space called a lacuna.
What happens to an osteoblast that becomes completely surrounded by bone matrix?
What happens to an osteoblast that becomes completely that becomes completely surrounded by bone matrix? the cell becomes an osteocyte. A bone cell, formed when a osteoblast becomes embedded in the matrix it has secreted.
Do osteoclasts secrete bone matrix and become osteoblasts?
Osteoclasts secrete bone matrix and become osteoblasts. Osteoblasts are large, multinucleated cells that break down calcified bone matrix.
How are osteoblasts incorporated into the bone matrix?
Osteoblasts (bone forming cells) are of mesenchymal origin, secrete non-mineralized bone matrix (osteoid), and finally become incorporated as osteocytes in mineralized bone matrix.
How are osteocytes connected to other bone cells?
Osteocytes communicate with one another and with cells at the bone surface via a meshwork of cell processes that run through canaliculi in the bone matrix (Palumbo et al., 1990 ). Thus, bone cells form a functional network within which cells at all stages of bone formation from preosteoblast to mature osteocyte remain connected.
Which is more abundant osteoblasts or osteocytes?
Osteocytes are by far the most abundant cellular component of mammalian bones, making up 95% of all bone cells (20,000 to 80,000 cells per mm 3 bone tissue) that cover 94% of all bone surfaces (Frost, 1960; Marotti, 1996 ); there are approximately ten times more osteocytes than osteoblasts in an individual bone (Parfitt, 1990 ).
When do mesenchymal cells differentiate into osteoblasts?
During intramembranous bone formation, mesenchymal cells differentiate into osteoblasts and bone is formed without replacing a cartilaginous model. Bones that form by this method are called membrane bones. Perichondral ossification is the most common mode of bone formation if a cartilaginous precursor is present.