Table of Contents
- 1 Is tolbutamide discontinued?
- 2 What happens when tolbutamide is given with sulfonamides?
- 3 When should tolbutamide be taken?
- 4 Is tolbutamide short or long acting?
- 5 What advice should be given while dispensing diphenhydramine?
- 6 What is the reason for unpredictable ADR?
- 7 What do you need to know about tolbutamide?
- 8 Is it safe to drink alcohol while taking tolbutamide?
Is tolbutamide discontinued?
A significant increase in total mortality was not observed, but the use of tolbutamide was discontinued based on the increase in cardiovascular mortality, thus limiting the opportunity for the study to show an increase in overall mortality.
What happens when tolbutamide is given with sulfonamides?
This gives a theoretical basis for being careful when tolbutamide and sulfonamides are co-administered. Hypoglycemia, often during the first hours of combining the two drugs, is the result of an important interaction between sulfonylureas and sulfonamides [211–214].
What is the mechanism of action of tolbutamide?
Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be able to produce insulin for this drug to work.
Which kind of interaction is observed between aspirin and tolbutamide?
aspirin TOLBUTamide Using aspirin together with insulin or certain other diabetes medications may increase the risk of hypoglycemia, or low blood sugar.
When should tolbutamide be taken?
Tolbutamide comes as a tablet to take by mouth. It is usually taken once a day in the morning. Tell your doctor if tolbutamide upsets your stomach. Your doctor may tell you to take smaller doses of tolbutamide more than once a day.
Is tolbutamide short or long acting?
Tolbutamide (Orinase) is a relatively short-acting compound whose indications are similar to the other orally effective hypoglycemic drugs.
How do you administer Tolbutamide?
Is tolbutamide an enzyme inhibitor?
Tolbutamide as a model drug for the study of enzyme induction and enzyme inhibition in the rat. Br J Pharmacol.
What advice should be given while dispensing diphenhydramine?
Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
What is the reason for unpredictable ADR?
Unpredictable ADRs occur due to a number of mechanisms, some of which are not currently understood. Nonetheless, there are a number of unpredictable ADRs for which the mechanism(s) underlying the pathology are understood in detail.
How do you administer tolbutamide?
Does tolbutamide cause hypoglycemia?
An overdose of tolbutamide can cause severe hypoglycemia. Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.
What do you need to know about tolbutamide?
Tolbutamide Description. Tolbutamide is an oral blood-glucose-lowering drug of the sulfonylurea class. Tolbutamide is a pure, white, crystalline compound which is practically insoluble in water. The chemical name is benzenesulfonamide, N-[(butylamino)-carbonyl]-4-methyl-.
Is it safe to drink alcohol while taking tolbutamide?
Drinking alcohol is not advisable with tolbutamide. If you do have a drink, keep well within the recommended alcohol limits, as alcohol will affect the control of your blood sugar. If you get unusually thirsty, pass urine more frequently, and feel very tired then let your doctor know.
How is tolbutamide used in the treatment of NIDDM?
Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating cells of the pancreas to release insulin.
Is it safe to take tolbutamide with sulfonylurea?
Some patients who are initially responsive to oral hypoglycemic drugs, including Tolbutamide, may become unresponsive or poorly responsive over time. Alternatively, Tolbutamide may be effective in some patients who have become unresponsive to one or more of the other sulfonylurea drugs.