Is Charcot-Marie-Tooth sex linked?

Is Charcot-Marie-Tooth sex linked?

In Charcot-Marie-Tooth disease (CMT) an autosomal as well as a sex-linked pattern of inheritance are described with both dominant and recessive forms existing. The sex-linked pattern has been reported on only a few occasions {Becker, 1966; de Recondo, 1975).

What type of disorder is CMT?

Charcot-Marie-Tooth (CMT) disease is an inherited nerve problem. It causes abnormalities in the nerves that supply your feet, legs, hands, and arms. It affects both your motor and sensory nerves. Motor nerves carry signals from your brain to your muscles, telling them to move.

Is Charcot-Marie-Tooth always genetic?

It is hereditary, meaning that it can be passed down through a family from one generation to the next. Because of these features, CMT is sometimes called hereditary motor and sensory neuropathy (HMSN).

What causes Charcot Marie Tooth disease ( CMTX )?

Type X Charcot-Marie-Tooth disease (CMTX) is caused by mutations in genes on the X chromosome, one of the two sex chromosomes. Within the various types of Charcot-Marie-Tooth disease, subtypes (such as CMT1A, CMT1B, CMT2A, CMT4A, and CMTX1) indicate different genetic causes.

What kind of neuropathy is Charcot Marie Tooth?

X-linked Charcot-Marie-Tooth neuropathy type 5 (CMTX5), part of the spectrum of PRPS1-related disorders, is characterized by peripheral neuropathy, early-onset (prelingual) bilateral profound sensorineural hearing loss, and optic neuropathy.

Can a person with Charcot Marie Tooth disease live?

A small percentage of people experience severe weakness or other problems which, in very rare cases, can be life-threatening. In most affected individuals, however, Charcot-Marie-Tooth disease does not affect life expectancy. Typically, the earliest symptoms of Charcot-Marie-Tooth disease result from muscle atrophy in the feet.

When does Charcot Marie Tooth Type 5 start?

X-linked Charcot-Marie-Tooth neuropathy type 5 (CMTX5), part of the spectrum of PRPS1-related disorders, is characterized by peripheral neuropathy, early-onset (prelingual) bilateral profound sensorineural hearing loss, and optic neuropathy. The onset of peripheral neuropathy is between ages five and 12 years.