Can I take antacids with methotrexate?

Can I take antacids with methotrexate?

Do not take indigestion remedies within 6 hours of Methotrexate. Avoid taking the antibiotics Septrin (Co-trimoxazole) or Trimethoprim when on Methotrexate as these increase the risk of side effects. Methotrexate tablets are made in two different strengths, 2.5mg and 10mg.

Can I take methotrexate with esomeprazole?

There is evidence to suggest that concomitant use of methotrexate (primarily at high doses) with PPIs such as omeprazole, esomeprazole, and pantoprazole may decrease methotrexate clearance, leading to elevated serum levels of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate …

What medications should not be taken with Nexium?

Esomeprazole (Nexium) can interact with many drugs, vitamins and herbal supplements. Common medications that should not be taken at the same time as esomeprazole (Nexium) include clopidogrel (Plavix), St. John’s Wort, rifampin (Rifadin), and methotrexate.

Does methotrexate cause heartburn?

Multivariate analysis revealed that higher dose MTX was independently associated reflux (OR: 1.62, 95% CI: 1.07–2.43) and abdominal pain (OR: 1.70, 95% CI: 1.12–2.59) (table 2). The odds ratio of reflux or abdominal pain in patients receiving high dose MTX was similar to that in patient receiving NSAIDs.

Why do you have to take folic acid with methotrexate?

Taking folic acid helps replenish the folate your body loses because of the methotrexate. By replenishing folate, folic acid supplementation can help prevent common methotrexate side effects like nausea, vomiting, and mouth sores.

Is 20mg of methotrexate a lot?

The usual maximum weekly adult dose for oral methotrexate is 20 milligrams (due to increased risk of bone marrow suppression). The usual oral pediatric dose of methotrexate for rheumatoid arthritis is 5 to 15 milligrams once weekly.

Can you take Nexium with methotrexate?

Nexium might increase the level of methotrexate in the blood, increasing the risk for methotrexate side effects. Check with your healthcare provider before combining these two medications. Rifampin may significantly decrease the level of Nexium in the blood, making it less effective.

What drugs interact with methotrexate?

A variety of drugs can affect how quickly methotrexate is absorbed or metabolized. Below, are the common antibiotics that can interact with methotrexate: Penicillin. Ciprofloxacin. Amoxicillin. Dapsone. Neomycin.

Does methotrexate interact with ibuprofen?

Methotrexate does have fairly significant interaction with ibuprofen, but they are often used together. Although this sounds somewhat confusing, in most cases, your dose of methotrexate will determine whether or not it is safe to use a pain reliever like ibuprofen.

Can you take Advil with methotrexate?

There are potential issues with taking the advil or aleve with the methotrexate medications, as the NSAID medication class (advil and aleve) can interact and make the methotrexate medication “build up” in the blood, making it potentially toxic.